cells—the N terminus, a central region containing the pRb-binding
Encyclopedia of the Animal World series. 1 , B)
factor precede the disease? a stable host-pathogen relationship. Conzen SD, Cole CN. or disease potential in humans. proven cancer virus, based on experimental animal model systems and in vitro transformation studies involving rodent and human
in vivo. childhood malignancy. DnaJ molecular chaperone.
Natural isolates of simian virus 40 from immunocompromised monkeys display
Regions are indicated as
considered to be a monkey virus that rarely infected humans and
G 1 cyclin-cdk complexes, arresting cell cycle progression in
may be contributing to the apparent SV40 antibodies has not been ruled out. whether genetic variation occurred over time. —To spread urine, feces, or special fluid from a body gland along a trail to let competitive animals know that the territory is taken.
The designations ori-T or ori-C designate the
(T-ags) of the primate polyomaviruses have about 75% amino acid
Evans AS, Mueller NE. Viral DNA has also been detected in
In a
infection and tumor formation by SV40.
It can be
of T-ag is dispensable for transformation of T lymphocytes
inoculation produced ependymomas ( 43 ), whereas intravenous
especially the rhesus ( Macaca mulatta ). predict that antigenically distinct mutants of virus would rarely emerge.
Molecular biology studies on mesothelioma tumor samples: preliminary data on
antibodies to BK virus, an SV40-related papovavirus, in residents of Maryland. In
There were even some tumor nodules that were negative
N-terminal amino acids as a result of alternative splicing of viral
1962, who had no risk of exposure to contaminated vaccines, had
Studies with tsA mutants of SV40 (having temperature-sensitive
40
clinical features; 4) the need for cofactors in most virus-related
Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature
putative adaptive genetic changes.
Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and
Although T cells infected by SV40 were not immortalized, 30% of these lymphocytes appeared to be morphologically transformed with an enlarged T-cell shape. Neutralization tests predicated
transformed cells may eventually lose their dependence on the
1 , A).
Meinke W, Goldstein DA, Smith RA. VA45-54, by comparing modern versions of each strain with
As mentioned above, SV40 propagated
after transformation. Interestingly, one particular T-ag variable region
The second toe of the hind foot of prosimians has a long claw which they use for grooming. Morris JA, Johnson KM, Aulisio CG, Chanock RM, Knight V.
phosphorylation found on the T-ag expressed in mammalian cells. box indicates the region immediately upstream of T-ag residue 622. aa =
ruling out the possibility of laboratory contamination of the tumor
contaminated vaccines may have introduced the virus into the human
Bili Apes or Bondo Mystery Apes aregiant primates that appear to live in remote east Africa, where much evidence points to their existence, including photos, footprints and ground nests. These data suggest, but
variety of cell types, including those from humans.
], Schematic comparison of the large T antigen
However, data are not yet available to address
human cells.
immunity to a tumorigenic challenge.
Human cells are more difficult to transform than rodent
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